Select your dosage form — Immediate-Release, ODT, Enteric-Coated, Sustained/Extended-Release, or Controlled-Release — and the standard USP/ICH sampling time points load automatically. Fill in your system configuration once, add vessel/unit readings per time point, and get % drug release, mean, SD, %RSD, and pass/fail against your own limits. Supports HPLC peak area or UV-Vis absorbance data.
Immediate-Release: 5, 10, 15, 20, 30, 45, 60 min | ODT: 5, 10, 15, 20, 30 min | SR / ER: 1, 2, 4, 6, 8, 12 h | ER (XR) / CR: up to 24 h
Dissolution Formula (same as the main Calculator)
% Result = (Area/Abs of Spl × Dilution Factor × Std Potency × Standard Weight × 100) ÷ (Area/Abs of Std × Label Claim × 100)
or, with optional API Factor:
% Result = (Area/Abs of Spl × Dilution Factor × Std Potency × Standard Weight × Factor × 100) ÷ (Area/Abs of Std × Label Claim × 100)
How to use: Select your dosage form — standard time points load automatically below. Fill in the System Configuration & System Suitability once — the same values are used for every time point. Add or remove time-point panels to match your SOP. Controlled-Release loads default points up to 24 hours (1440 min) — add more manually if your protocol needs them.
Select Dosage Form
Enteric-coated products are always tested as two separate runs — pick which phase you're recording now. Switch the selection above (or reset and select again) to record the other phase. Acid Phase: 2 h (120 min) in acid medium (pH 1.2) — confirms enteric coating integrity. Buffer Phase: 15, 30, 45, 60, 90 min in buffer (pH 6.8) — measures actual drug release.
System Configuration & Constants
Select the instrument used for analysis — all field labels below update automatically with this selection
Required for UV-Vis — choose the range that applies to your readings
From your balance record (e.g. 20.0)
From your standard CoA (e.g. 100.0)
Combined dilution factor for standard & sample preparation (as per SOP).
Total volume of dissolution medium per vessel. Documentation only — not used in the % Release formula.
API content stated on the product label per dosage unit
Only fill if your method requires an API correction factor
Standard System Suitability
Covering Standard is OFF — only the System Suitability readings above are used for every time point.
Standard Injections: Count = 0 | Mean = 0.00 | SD = 0.00 | % RSD = 0.00%
Dissolution Time Points
⚠️ Disclaimer
BestPharmaTools.com provides this Dissolution by Dosage Form Calculator strictly for educational and informational purposes. It is an independent, unaffiliated online tool and is not a validated laboratory instrument, controlled GMP document, or a substitute for your organization's approved Quality Management System, Standard Operating Procedures, or review by qualified QA/QC personnel. All data entered is provided solely by the user; BestPharmaTools.com does not verify, endorse, or take responsibility for its accuracy, completeness, or suitability for any regulatory, clinical, or commercial use. Any output — including results viewed, copied, or printed — is used entirely at the user's own discretion and risk. BestPharmaTools.com and its owners/affiliates accept no liability for any decisions, actions, losses, or damages arising from use of this tool. Always verify calculations independently and follow your organization's validated systems and approved SOPs for any official, regulatory, or GMP-related documentation.
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